The opening week of the 2025 regular season features spotlight games in Philadelphia, Sao Paulo, Buffalo and Chicago, and oddsmakers generally leaned toward the home teams with the early lines released Wednesday.
The Super Bowl champion Philadelphia Eagles are a seven-point favorite over the Dallas Cowboys in the 2025 Kickoff Game, and the Pittsburgh Steelers are road favorites against the New York Jets in the only game with a point total under 40 in Week 1.
Here’s a full rundown of 2025 odds (courtesy of FanDuel) for all games scheduled Sept. 4-8:
Thursday, Sept. 4
Dallas Cowboys at Philadelphia Eagles (-6.5)
8:20 p.m. ET on NBC, Lincoln Financial Field, Philadelphia
Money line: Eagles -330, Cowboys +265
Total: 46.5 points
Friday, Sept. 5
Kansas City Chiefs (-2.5) vs. Los Angeles Chargers
8 p.m. ET on YouTube, Corinthians Arena, Sao Paulo
Money line: Chiefs -142, Chargers +120
Total: 44.5 points
Sunday, Sept. 7
New York Giants at Washington Commanders (-7)
1 p.m. ET, Northwest Stadium, Landover, Md.
Money line: Commanders -350, Giants +280
Total: 45.5 points
Tampa Bay Buccaneers (-1.5) at Atlanta Falcons
1 p.m. ET, Mercedes-Benz Stadium, Atlanta
Money line: Buccaneers -126, Falcons +108
Total: 48.5 points
Carolina Panthers at Jacksonville Jaguars (-2.5)
1 p.m. ET, EverBank Stadium, Jacksonville
Money line: Jaguars -144, Panthers +122
Total: 46.5 points
Miami Dolphins at Indianapolis Colts (-1)
1 p.m. ET, Lucas Oil Stadium, Indianapolis
Money line: Dolphins -104, Colts -116
Total: 45.5 points
Las Vegas Raiders at New England Patriots (-2)
1 p.m. ET, Gillette Stadium, Foxborough, Mass.
Money line: Patriots -156, Raiders +132
Total: 43.5 points
Pittsburgh Steelers (-3) at New York Jets
1 p.m. ET, MetLife Stadium, East Rutherford, N.J.
Money line: Steelers -156, Jets +132
Total: 39.5 points
Cincinnati Bengals (-5.5) at Cleveland Browns
Money line: Bengals -240, Browns +198
Total: 45.5 points
Arizona Cardinals (-4.5) at New Orleans Saints
1 p.m. ET, Caesars Superdome, New Orleans
Money line: Cardinals -200, Saints +168
Total: 41.5 points
San Francisco 49ers (-1.5) at Seattle Seahawks
4:05 p.m. ET, Lumen Field, Seattle
Money line: 49ers -124, Seahawks +106
Total: 45.5 points
Tennessee Titans at Denver Broncos (-7)
4:05 p.m. ET, Empower Field at Mile High, Denver
Money line: Broncos -350, Titans +280
Total: 41.5 points
Detroit Lions (-1.5) at Green Bay Packers
4:25 p.m. ET, Lambeau Field, Green Bay, Wis.
Money line: Lions -122, Packers +104
Total: 49.5 points
Houston Texans at Los Angeles Rams (-2.5)
4:25 p.m. ET, Sofi Stadium, Inglewood, Calif.
Money line: Rams -146, Texans +124
Total: 46.5 points
Baltimore Ravens at Buffalo Bills (-1.5)
8:20 p.m. ET on NBC, Highmark Stadium, Orchard Park, N.Y.
Money line: Bills -122, Ravens +104
Total: 51.5 points
Monday, Sept. 8
Minnesota Vikings (-1.5) at Chicago Bears
8:15 p.m. ET on ESPN/ABC, Soldier Field, Chicago
Money line: Vikings -110, Bears -106
Total: 45.5 points
